ENDOCRINE SYSTEM INDICATORS SOFTWARE

Biological networks of the two patterns and their various characterizations were separately constructed by using two literature-mining methods.

ENDOCRINE SYSTEM INDICATORS SOFTWARE

Two different literature-mining software PubMiner and GenCliP, were used on the principle of 'pattern-characterization-biological indicator' co-occurrence to find the characteristic NEI gene and the chemical messenger (CM) of Qi deficiency and qi stagnation patterns and to explore the difference in the bioactive substances between the two patterns, such as Hormones, Receptors, Cytokine, Neurotransmitters, etc. Relevant literatures about the characterizations of these two patterns can be found on PubMed. A neuro-endocrine-immune (NEI)-related gene data dictionary and a human phenotype ontology (HPO) characterizations terminology database have been established for these two patterns. Furthermore, the results will be validated by clinical data to examine the methodological reliability. The aim of this paper is to distinguish two common Chinese medicine patterns, qi deficiency pattern and qi stagnation pattern, and their characterizations in terms of internal biology by using literature-mining methods. Therefore, it is a better method to construct and analyze the 'pattern-characterization-biological indicator' network. If the relationship of every characterization and its biological indicators can be structured, and of each pattern and its biological indicators, it will help us to understand TCM better. From our study, a pattern consisting of many kinds of characterizations has been found, and every characterization corresponds with its internal biological indicators.

The key to break through this problem is to make the right methodological choices. Nowadays, it is quite challenging to clarify Chinese medicine's results and its internal biological foundation in the traditional Chinese medicine (TCM) field. ZHAI, XING FENG, XUANCHAO LIU, JINGWEI GAO, KUO JIA, ZHENHUA ZHAO, HUIHUI WANG, JUAN WANG, WEI CHEN, JIANXIN By its toxic action on the kidney or liver, a pollutant can also alter the hormonal balance by modifying the metabolism of hormones, their half-life in blood, their activities, and their rate of elimination.NEURO-ENDOCRINE-IMMUNE BIOLOGICAL NETWORK CONSTRUCTION OF QI DEFICIENCY PATTERN AND QI STAGNATION PATTERN IN TRADITIONAL CHINESE MEDICINE NEURO-ENDOCRINE-IMMUNE BIOLOGICAL NETWORK CONSTRUCTION OF QI DEFICIENCY PATTERN AND QI STAGNATION. A pollutant can alter endocrine function by acting on processes of hormone synthesis and release in the hypothalamus, the anatomical and functional link with the nervous system, and similarly in the hypophysis and target glands, those that depend on hypophysial trophic hormones as well as others (Fig. Therefore, any significant alteration of hormonal balance induced by xenobiotics may alter the physiological performance of the organism as well as its capacity to ensure its survival and transmission of its genetic patrimony. It is characterized by the action of specific hormones on multiple cellular targets and by the regulation of hormone levels in blood at several levels (hypothalamus, hypophysis, and target glands).

Moreover, the 188hormonal action is an integrated process.

The sensitivity of the hormonal response, which generally precedes the expression of pathologies in tissues and organs or mortality (Hontela et al., 1993a), is a key characteristic of early indicators of damage induced by xenobiotics. The consensus that emerges, supported by an increasing number of experimental studies, is that certain pollutants disturb the endocrine function and cause physiological anomalies through a hormonal imbalance (Colborn and Clement, 1992). Studies in environmental toxicology have proved the harmful effects of certain pollutants on the physiological performance of fishes and other aquatic organisms (Heath, 1987). Osmoregulation, metabolism, growth, and reproduction are hormone-dependent physiological functions that are constantly modulated in response to environmental stimuli (Hontela and Stacey, 1990 Rankin and Jensen, 1993). The endocrine system plays an important role in maintenance of physiological integrity by allowing, through its hormonal effectors, the regulation of homeostatic response of the organism in reaction to fluctuations of environmental factors. Nychthemeral, seasonal, and annual changes in factors such as temperature, photoperiod, and availability of food imply a precise synchronization and adjustment of vital physiological functions. The environment is a multifactorial matrix in which an organism must, in order to ensure its survival, constantly prove its capacity for physiological homeostasis.

Endocrine system indicators